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4 months (95% confidence interval [CI] 6.5, 8.8) with abemaciclib and 7.8 months (95% CI 6.4, 9.5) with erlotinib (hazard ratio [HR] = 0.968 [95% CI 0.768, 1.219]; p = .77). Median PFS was 3.6 months (95% CI 2.8, 3.8) with abemaciclib and 1.9 months (95% CI 1.9, 2.0) with erlotinib (HR = 0.583 [95% CI 0.470, 0.723]; p <.000001). ORR was 8.9% and…Read more

Riboflavin (seven studies, n 1953) inadequacy progressively increased with age; the prevalence of inadequacy increased from baseline by up to 22·6 and 9·3 % in males and females, respectively. Dietary folate adequacy (three studies, n 2321) improved in two studies (by up to 22·4 %), but the third showed increasing (8·1 %) inadequacy. Evidence was…Read more

We experimentally demonstrate this new type of key exchange method by encoding information into a few-photon light pulse decomposed over guided modes of an easily available multimode fiber.The limited dynamic range of regular screens restricts the display of high dynamic range (HDR) images. Inspired by retinal processing mechanisms, we propose a…Read more

131). We saw a decrease in opioid use (study 47.4%, control 60.0%, p  less then  0.01) and an increased use of non-opioid analgesics (study 27.3%, control 18.44%, p  less then  0.01). CONCLUSIONS Removing IV morphine in the ED, without a compensatory rise in alternative opioids, does not appear to significantly impact analgesia or disposi…Read more

BACKGROUND To test whether children awaken from slow wave sleep and perform an escape procedure better in response to a smoke alarm that uses a male voice, female voice, combination of a low-frequency tone plus a female voice (hybrid alarm), or high-frequency tone. METHODS Using a randomized, non-blinded, repeated-measures design, 188 children…Read more

Riboflavin (seven studies, n 1953) inadequacy progressively increased with age; the prevalence of inadequacy increased from baseline by up to 22·6 and 9·3 % in males and females, respectively. Dietary folate adequacy (three studies, n 2321) improved in two studies (by up to 22·4 %), but the third showed increasing (8·1 %) inadequacy. Evidence was…Read more

We experimentally demonstrate this new type of key exchange method by encoding information into a few-photon light pulse decomposed over guided modes of an easily available multimode fiber.The limited dynamic range of regular screens restricts the display of high dynamic range (HDR) images. Inspired by retinal processing mechanisms, we propose a…Read more

The factors associated with sinus barotrauma were pollen allergies (OR 1.59; 95% CI 1.10-2.29), regular smoking (OR 2.04; 95% CI 1.07-3.91) and a high number of upper respiratory tract infections per year (≥ 3 vs. < 3 infections per year OR 2.76; 95% CI 1.79-4.24).

Sinus barotrauma is the second most common condition encountered in d…Read more