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We propose a model whereby RB can regulate DSB repair pathway choice by mediating the CtIP dependent DNA end resection. The use of PARP1 inhibitor could potentially improve treatment outcomes for RB-deficient cancers.Dental-care workers operate very close to the patient’s mouth and are at high risk of contamination by SARS-CoV-2. Droplets may be…Read more

Cortical venous thrombosis (CVT) mostly occurs due to a hypercoagulable state. Infection- related CVT is very rare and is a medical emergency associated with a very high mortality rate. It has been described with bacterial and fungal infections; but only a few isolated case reports of CVT related to tubercular meningitis (TBM) exist. Only six…Read more

The results showed that the mycelial cultures of the studied species may be used as an alternative source of substances used in cosmetology.The co-application of exogenous 100 µM melatonin (MT) and 100 µM salicylic acid (SA) on 21-day-old safflower seedlings grown in the presence of cadmium (Cd, 100 µM) toxicity was investigated. The applicat…Read more

Although membrane aerated biofilm reactor (MABR) is promising in nitrogen removal due to its counter-diffusion biofilms structure, it still cannot adapt a wider COD/N ratios wastewater. In this condition, expanding the MABR applicability range in different COD/N ratio wastewater is necessary. In this study, a bacterial-algae biofilm, instead of…Read more

Objectives A definitive diagnosis of malignancy may not be possible in pleural effusions. We report our experience with the diagnosis of suspicious for malignancy (SFM) in pleural effusion. Methods A search for pleural effusions diagnosed as SFM (2008-2018) was performed. Patient records and pathology reports were reviewed. Specimens were…Read more

In the subgroup analyses, however, high temperatures were significantly associated with an increased risk of cardiovascular mortality among those 75 years old and older, with the strongest effect observed on day 0 relative to exposure. The results revealed a lack of interactive effects between temperature and air pollutants on cardiovascular and…Read more

BACKGROUND Vitamin D deficiency increases the risk of developing multiple sclerosis (MS) but it is unclear whether vitamin D supplementation improves the clinical course of MS, and there is uncertainty about the dose and form of vitamin D (D2 or D3) to be used. The mechanisms underlying the effects of vitamin D in MS are not clear. Vitamin D3…Read more

Further understanding and revealing the impacts of the PC on the biological behavior of GNPs can be a promising and important strategy to regulate and improve the performance of GNP-based biosystems in the future. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Patients with severe hyponatremia and renal failure who require continuous renal…Read more